thymidylatesynthase

2024年3月5日 — Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as ...

由 L Costantino 著作 · 2022 · 被引用 3 次 — Drugs that target human thymidylate synthase (hTS), a dimeric enzyme, are widely used in anticancer therapy.

由 BG Le François 著作 · 2007 · 被引用 36 次 — Thymidylate synthase (TS) is the enzyme that catalyses the last step in de novo thymidylate synthesis. It is of interest clinically because ...

由 D Chen 著作 · 2017 · 被引用 55 次 — Abstract. Thymidylate synthase (TS) is the sole enzyme responsible for de novo biosynthesis of thymidylate (TMP) and is essential for cell ...

Thymidylate synthase is an enzyme of about 30 to 35 kDa in most species except in protozoan and plants where it exists as a bifunctional enzyme that includes a ...

catalyzes the reductive methylation of dUMP to dTMP with concomitant conversion of 5,10-methylenetetrahydrofolate to dihydrofolate: 5 ...

Thymidylate synthase converts deoxyuridine monophosphate to thymidine monophosphate. 5-FU administration reduces deoxythymidine monophosphate, blocks DNA ...

Thymidylate synthase catalyzes the methylation of dUMP to dTMP using 5,10-methylenetetrahydrofolate as a cofactor. TS is essential for DNA replication and ...

由 A Siddiqui 著作 · 2019 · 被引用 34 次 — Thymidylate synthase (TS) is the enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to thymidine monophosphate (dTMP or ...